| 发明名称 | Use of Toll-Like Receptor agonist for treating cancer | ||
| 摘要 | The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist. | ||
| 申请公布号 | US9376473(B2) | 申请公布日期 | 2016.06.28 |
| 申请号 | US201213979104 | 申请日期 | 2012.01.10 |
| 申请人 | Cleveland BioLabs, Inc. | 发明人 | Gleiberman Anatoli;Burdelya Lyudmila;Gudkov Andrei |
| 分类号 | A61K38/16;A61K39/02;A61K39/112;C07K14/195;C07K14/255;A61K39/395;C07K16/28;C07K14/705 | 主分类号 | A61K38/16 |
| 代理机构 | Morgan, Lewis & Bockius LLP | 代理人 | Morgan, Lewis & Bockius LLP |
| 主权项 | 1. A method of treating a cancer that does not express Toll-Like Receptor 5 (TLR5) in a subject in need thereof, comprising administering to the subject an effective amount of a TLR5 agonist, wherein the cancer is present in a liver tissue that expresses TLR5, and wherein the TLR5 agonist is flagellin or a flagellin derivative. | ||
| 地址 | Buffalo NY US | ||