发明名称 |
HUMAN MESOTHELIN CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF. |
摘要 |
Provided are compositions and methods for treating diseases associated with expression of mesothelin. Also provided are a chimeric antigen receptor(CAR) specific to mesothelin, vectors encoding the same, and recombinant T cells comprising the mesothelin CAR. Further provided are methods of administering a genetically modified T cell expressing a CAR that comprises a mesothelin binding domain. |
申请公布号 |
MX2016008076(A) |
申请公布日期 |
2016.08.12 |
申请号 |
MX20160008076 |
申请日期 |
2014.12.19 |
申请人 |
NOVARTIS AG |
发明人 |
Carl H. JUNE;Andreas LOEW;Gregory BEATTY;Boris ENGELS;Neeraja IDAMAKANTI;Huijuan SONG;Qilong WU |
分类号 |
C12N15/62;A61K48/00;A61P35/00;C07K14/725;C07K16/46;C12N15/13;C12N15/63 |
主分类号 |
C12N15/62 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|