HUMAN C3B/C4B RECEPTOR (CR1)

摘要

The present invention relates to the C3b/C4b receptor (CR1) gene, its encoded protein, and CR1 nucleic acid sequences and fragments thereof comprising 70 nucleotides and their encoded peptides or proteins comprising 24 amino acids. The invention further provides for the expression of the CR1 protein and fragments thereof. The genes and proteins of the invention have uses in diagnosis and therapy of disorders involving complement activity, and various embodiments of the present invention include the cloning, nucleotide sequence and deduced amino acid sequence of a full-length CR1 cDNA and fragments thereof. The expression of the CR1 protein and fragments thereof is also described as is the expression of a secreted CR1 molecule lacking a transmembrane region which is useful in reducing damage caused by inflammation and in reducing myocardial infarct size and preventing reperfusion injury.