2-CARBONYLTHIAZOLE DERIVATIVES AND USE OF THE SAME

摘要

2-Carbonylthiazole derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof (wherein Ar<1> and Ar<2> represent each phenyl optionally having one or two substituents selected from among halogeno, C1-5 alkyl, trifluoromethyl, C1-5 alkoxy and hydroxy or thienyl; R<1> represents C1-5 alkoxy, hydroxy or amino represented by the formula N(R<3>)R<4> (wherein R<3> and R<4> represent each hydrogen or C1-5 alkyl, or R<3> and R<4> together with the nitrogen atom to which they are bonded may form pyrrolidino, piperidino, morphorino or piperazino optionally having one to four substituents selected from among C1-5 alkyl, C1-5 alkoxy and hydroxy); Y<1>-Y<2> represents CH-CO or C=C(R<2>) (wherein R<2> represents hydrogen or C1-5 alkyl); and n is an integer of 1 to 4); drugs comprising the derivatives represented by the above general formula (I) or pharmaceutically acceptable salts thereof; and dopamine D4 receptor antagonists containing as the active ingredient the same. These drugs are useful as preventives and remedies for various diseases in which dopamine D4 receptors participate, for example, schizophrenia, cerebrovascular disorders and problematic behaviors accompanying senile dementia without showing any extrapyramidal disorders as the side effect.