METHODS AND PRODUCTS FOR FACILE MICROBIAL EXPRESSION OF DNA SEQUENCES

摘要

Disclosed is a method for constructing a DNA sequence encoding a desired polypeptide in such a manner as to insure that, on transcription in an appropriate host, the corresponding messenger RNA demonstrates levels of conformational structure insufficient to interfere with its accessibility for efficient ribosomal translation. The production of bovine growth hormone is illustrative of the invention.