E1B-DELETED ADENOVIRAL SHUTTLE VECTORS

摘要

Provided are replication competent, recombinant adenovirus vectors containin g mutations in the E1B region which permit the easy deletion of a gene or gene s therein, and optionally the substitution therefore of a heterologous gene th at substantially exhibits the temporal expression pattern of the E1b region gene(s) deleted. Such vectors have applications for the treatment of disease , and preferably for the treatment of neoplastic disease.