| 摘要 |
DNAs encoding polypeptides which cleave telomeric repeats are successfully isolated form a retrotransposon-like sequences present in the telomeric repeats of genomic DNA. The polypeptides encoded by the above DNAs show an activity of cleaving telomeric repeats of insects and vertebrates. Thus, polypeptides cleaving telomeric repeats, DNAs encoding these polypeptides an d the production and use thereof are provided. These polypeptides are usable i n specifically cleaving telomeric repeats. Moreover, these polypeptides are applicable to the control of cell aging and treatment of cancer.
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