发明名称 |
Compositions containing full-length L1R nucleic acid and endoplasmic reticulum-targeting sequence, and methods of use |
摘要 |
The invention described here encompasses DNA and protein vaccines against poxviruses, and relevant immunogenic compositions, comprising at a minimum a nucleic acid encoding a modified full-length poxvirus L1R gene or its ortholog. The L1R gene is modified so that an endoplasmic reticulum-targeting sequence is operably linked on the 5' end. Preferably the nucleic acid sequences for other poxviruses antigens are also included, such as A33R, B5R and/or A27L. These vaccines and compositions provide improved neutralizing antibody response elicited by molecular poxvirus vaccines, over known vaccines using unmodified L1R.
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申请公布号 |
US2009074792(A1) |
申请公布日期 |
2009.03.19 |
申请号 |
US20080217584 |
申请日期 |
2008.07.07 |
申请人 |
HOOPER JAY W;GOLDEN JOSEPH W |
发明人 |
HOOPER JAY W.;GOLDEN JOSEPH W. |
分类号 |
A61K39/395;A61K31/7052;A61K39/275;A61P31/12;A61P37/04;C07H21/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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