SYSTEM, METHOD, AND LUMINESCENT MARKER FOR IMPROVED DIFFUSE LUMINESCENT IMAGING OR TOMOGRAPHY IN SCATTERING MEDIUM

摘要

PROBLEM TO BE SOLVED: To disclose a method and system for luminescence molecular imaging or tomography of a region of interest in a scattering medium.SOLUTION: The system comprises a nonlinear luminescent marker material arranged in the scattering medium. Contrast and resolution of the imaging or tomography are thus improved. The nonlinear marker is, for example, configured to upconvert incoming light of an illumination wavelength. The nonlinear power dependence of the marker enables further improvement of the imaging by using images taken with two or more excitation beams simultaneously.SELECTED DRAWING: Figure 9