RECOMBINANT TOXIN WITH INCREASED HALF-LIFE

摘要

The present invention relates to the production and use of recombinant toxins modified to increase their half-life and thereby increasing their potency during therapy. More particularly, this invention relates to the use of regions of the Fc portion of an immunoglobulin molecule to confer an increased half-life on single chain chimeric toxins that include a ligand binding domain such as from CD4 receptor and a cytotoxic domain such as from (Pseudomonas exotoxin) A.