| 摘要 |
Transition metals such as copper and iron, alone or in combination with each other or other transition metals, in aqueous solution are able to inactivate bacteria fungi, and viruses with an efficiency similar to that of substances usually recommended for disinfection and sterilization. Other transition metals can be used as disinfectant and sterilizing agents. The inactivating efficiency of such metals can be greatly enhanced by the addition of hydrogen peroxide, other peroxides, or pero-generating agents. The microbicidal potency of such mixtures can be increased even further in a ternary system composed of metal(s), peroxide, and a chelator, such as nitrilotriacetic acid (NTA). Different formulations of mixtures of metals and peroxide with or without NTA are provided. These are capable of inactivating viruses, bacteria, and fungi with an efficiency higher than that exhibited by substances currently in use. Also provided are methods for inactivating microorganisms for vaccine development, sterilizing or disinfecting medical devices and fluids, treating infectious disease, and assaying disinfectant, sterilizing, and antimicrobial substances and complex mixtures for microbicidal efficiency. |
