| 摘要 |
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertensi on or glaucoma therapeutically effective amount of a compound represented by th e general formula (I), wherein hatched lines represent the .alpha. configuration, a triangle represents the .beta. configuration and a dotted line represents the presence or absence of a double bond; A and B are independently selected from the group consisting of O, S and CH2 provided th at at least one of A or B is S; D represents a covalent bond or CH2, O, S or NH ; X is CO2R, CONR2, CH2OR, P(O)(OR)2, CONRSO2R SONR2 or Y is O, OH, OCOR2, halogen or cyano; Z is CH2 or a covalent bond; R is H or R2; R1 is H, R2, phenyl, or COR2; R2 is C1-C5 lower alkyl and R3 is C1-C5 n-alkyl, C3-C7 cycloalkyl, phenyl, furanyl, thienyl, or substituted derivatives thereof, wherein the substituents may be selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, CO2R and OR.
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