| 摘要 |
A 3,4-dihydroquinazoline derivative is provided to be usefully used as an active ingredient of an anti-cancer agent by showing strong growth inhibitory activity on various human cancer cell lines. An anti-cancer agent composition comprises a 3,4-dihydroquinazoline derivative represented by the formula(1) or a pharmaceutically acceptable salt thereof as an effective ingredient. In the formula(1), R1 is 5-aminopentyl amino, dimethyl amino or piperidine-1-yl; R2 is 4-biphenyl, ethyl or phenyl; and R3 is methoxy, benzylamino, 4-aminobenzylamino, 4-fluorobenzenesulfoneaminobenzyl or 4-methylbenzenesulfoneaminobenzyl. The composition is applied to the cancer selected from the group consisting of lung cancer, colon carcinoma, epidermoid, malignant melanoma and uterine carcinoma.
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