New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
申请公布号
ZA200800506(B)
申请公布日期
2009.11.25
申请号
ZA20080000506
申请日期
2008.01.17
申请人
NOVARTIS AG
发明人
AIKAWA, MINA E.;DOVE, JEFFREY H.;MCBRIDE, CHRISTOPHER;POON, DANIEL J.;RENHOWE, PAUL A.;STUART, DARRIN;AMIRI, PAYMAN;LEVINE, BARRY HASKELL;PICK, TERESA E.;RAMURTHY, SAVITHRI;SHAFER, CYNTHIA;SUBRAMANIAN, SHARADHA