摘要 |
The present invention relates to methods, systems and compositions, including genetically modified microorganisms, adapted to exhibit increased tolerance to 3-hydroxypropionic acid (3-HP), particularly through alterations to interrelated metabolic pathways identified herein as the 3-HP toleragenic pathway complex ("3HPTGC"). In various embodiments these organisms are genetically modified so that an increased 3-HP tolerance is achieved. Also, genetic modifications may be made toprovide at least one genetic modification to any of one or more 3-HP biosynthesis pathways in microorganisms comprising one or more genetic modifications of the 3HPTGC. |
申请人 |
OPX BIOTECHNOLOGIES, INC;THE REGENTS OF THE UNIVERSITY OF COLORADO;WARNECKE-LIPSCOMB, TANYA, E.;LYNCH, MIKE, D.;GILL, RYAN, T. |
发明人 |
WARNECKE-LIPSCOMB, TANYA, E.;LYNCH, MIKE, D.;GILL, RYAN, T. |