| 发明名称 |
Biosensors Engineered from Conditionally Stable Ligand-Binding Domains |
| 摘要 |
Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs. |
| 申请公布号 |
US2016202256(A1) |
申请公布日期 |
2016.07.14 |
| 申请号 |
US201614993509 |
申请日期 |
2016.01.12 |
| 申请人 |
President and Fellows of Harvard College ;University of Washington |
发明人 |
Church George M.;Feng Justin;Mandell Daniel J.;Baker David;Fields Stanley;Jester Benjamin Ward;Tinberg Christine Elaine |
| 分类号 |
G01N33/566;G01N33/74 |
主分类号 |
G01N33/566 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A biosensor comprising a ligand binding domain (LBD) engineered to respond conditionally to the presence of specific small molecules, the biosensor including an LBD that is fused to a reporter protein or transcription factor (TF). |
| 地址 |
Cambridge MA US |
