发明名称 Therapeutic prostaglandin receptor agonists
摘要 Described herein are compounds which can be used in topical liquids, creams, or other dosage forms such as solids, for reducing intraocular pressure, treating glaucoma, growing hair, treating wounds, or other medical and/or cosmetic uses.
申请公布号 US9394273(B2) 申请公布日期 2016.07.19
申请号 US201514712105 申请日期 2015.05.14
申请人 ALLERGAN, INC. 发明人 Donde Yariv;Nguyen Jeremiah H.
分类号 C07D333/62;C07C405/00;C07D319/18;C07D333/54;A61K8/49;A61Q7/00;C07C63/66;C07D333/56;C07D319/16;A61K8/368;C07D333/60 主分类号 C07D333/62
代理机构 代理人 Bass Jonathan
主权项 1. A compound represented by Formula 1:or a pharmaceutically acceptable salt thereof, wherein: a dashed line indicates the presence or absence of a double bond; Q is CO2R1, CH2OR1, CONR1R2, or optionally substituted tetrazol-5-yl, wherein R1 and R2 are independently H, C1-6 alkyl, C1-6 hydroxyalkyl, morpholinoethyl, or optionally substituted phenyl; Ph1 is optionally substituted interphenylene; a and b are independently 0, 1, or 2; X is CH2, O, or S; n is 0, 1, or 2; and Ar is optionally substituted aryl or optionally substituted heteroaryl.
地址 Irvine CA US