Immunostimulatory G, U-containing oligoribonucleotides

摘要

Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8). The compositions and methods are useful for stimulating immune activation. Methods useful for screening candidate immunostimulatory compounds are also provided.

主权项

1. A synthetic G,U-rich immunostimulatory RNA oligomer which is 15-40 nucleotides long comprising multiples of 5′-GUUGB-3′, wherein B represents U, G, or C; wherein the multiples are linked through a single intervening linking nucleoside, which is selected from the group consisting of G and U.