| 发明名称 | Precursor compounds for the radiosynthesis of [<sup>18</sup>F] norchloro-fluorohomoepibatidine | ||
| 摘要 | The invention relates to a compound of formula Ia or Ib wherein R1 represents —CO2R3, —COR4 or —R5, wherein R3 represents unsubstituted or substituted C1-C6 alkyl, R4 represents hydrogen, unsubstituted or substituted C1-C6 alkyl, and R5 represents hydrogen, unsubstituted or substituted C1-C6 alkyl, R2 represents —N+(R6)(R7)(R8)X− or a nitro group, wherein R6, R7, R8 independently of each other represent unsubstituted or substituted C1-C6 alkyl or unsubstituted or substituted —(CH2)n- with n=1 to 12 provided that at least two of the substituents R6R7R8 are C1-C6 alkyl, and X− represents a halide, sulphonate, unsubstituted or substituted acetate, sulphate, hydrogen sulphate, nitrate, perchlorate, or oxalate. | ||
| 申请公布号 | US9428497(B2) | 申请公布日期 | 2016.08.30 |
| 申请号 | US201214236801 | 申请日期 | 2012.07.31 |
| 申请人 | ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBH;HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF E.V.;UNIVERSITAET LEIPZIG | 发明人 | Smits René;Hoepping Alexander;Fischer Steffen;Hiller Achim;Deuther-Conrad Winnie;Brust Peter;Steinbach Jörg;Patt Marianne;Patt Jörg Thomas;Sabri Osama |
| 分类号 | C07D451/00;C07D451/04;C07D451/02 | 主分类号 | C07D451/00 |
| 代理机构 | Maier & Maier, PLLC | 代理人 | Maier & Maier, PLLC |
| 主权项 | 1. A compound of formula Ia or Ib wherein R1 represents —CO2R3, —COR4 or —R5, wherein R3 represents unsubstituted or substituted C1-C6 alkyl,R4 represents hydrogen, unsubstituted or substituted C1-C6 alkyl, andR5 represents hydrogen, unsubstituted or substituted C1-C6 alkyl, R2 represents —N+(R6)(R7)(R8)X−or nitro, wherein R6, R7, R8 independently of each other represent unsubstituted or substituted C1-C6 alkyl or unsubstituted or substituted —(CH2)n— with n=1 to 12 provided that at least two of the substituents R6, R7, and R8 are C1-C6 alkyl, andX− represents a halide, sulphonate, unsubstituted or substituted acetate, sulphate, hydrogen sulphate, nitrate, perchlorate, or oxalate. | ||
| 地址 | Radeberg DE | ||