Bis-(aryl/heteroaryl)-methylene compounds, pharmaceutical compositions containing same and their use for treating cancer

摘要

The present disclosure relates to novel compounds having vitamin D receptor agonist and histone deacetylase inhibitory efficacy as well as methods for reducing or inhibiting the proliferation of cancer cells or for treating cancer.;

主权项

1. A compounds of formulaor a pharmaceutically acceptable salt thereof, wherein
the dotted line is an optional double bond; A and B are each independently an aryl; R1 is hydrogen, an alkyl or cycloalkyl; R2 is absent when the dotted line is a double bond or R2 is hydrogen, an alkyl or cycloalkyl when the dotted line is absent; W is OH when the dotted line is absent or W is O when the dotted line is a double bond; X is O, CH2, CHR7 or CR7R7, where R7 is in an alkyl or fluoroalkyl; Y is NR10(CO), (CO)NR10, O, CH2, CHR7 or CR7R7, where R7 is in an alkyl or fluoroalkyl and R10 is H or an alkyl; R3 and R4 are each independently hydrogen, an alkyl or fluoroalkyl; R5 and R6 are each independently an optional substituent; when p is greater than 0, R″ is H and one of said R″ is optionally OH; n and p are each an integer from 0 to 6.