| 发明名称 |
Synthesis of an antiviral compound |
| 摘要 |
The present disclosure provides processes for the preparation of a compound of formula I:;
which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I. |
| 申请公布号 |
US9440991(B2) |
申请公布日期 |
2016.09.13 |
| 申请号 |
US201414576143 |
申请日期 |
2014.12.18 |
| 申请人 |
Gilead Sciences, Inc. |
发明人 |
Cagulada Amy;Chan Johann;Chan Lina;Colby Denise A.;Karki Kapil Kumar;Kato Darryl;Keaton Katie Ann;Kondapally Sudha;Levins Chris;Littke Adam;Martinez Ruben;Pcion Dominika;Reynolds Troy;Ross Bruce;Sangi Michael;Schrier Adam J.;Seng Pamela;Siegel Dustin;Shapiro Nathan;Tang Donald;Taylor James G.;Tripp Jonathan;Waltman Andrew W.;Yu Lawrence |
| 分类号 |
C07D403/12;C07D413/14;C07D498/16;C07C227/02;C07D453/02;C07C209/00;C07C51/09;C07K5/083 |
主分类号 |
C07D403/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for preparation of a compound of formula V: or a salt thereof; comprising contacting a compound of formula III or a salt thereof, with a compound of formula IV: under O-arylation conditions to provide the compound of formula V or a salt thereof, wherein R is C1-6 alkyl, PG is a protective group, and R1 is a leaving group. |
| 地址 |
Foster City CA US |
