Solid state forms of vemurafenib hydrochloride

摘要

Provided herein are solid state forms of Vemurafenib hydrochloride, processes for preparing the solid state forms, as well as pharmaceutical compositions and formulations comprising said solid state forms.

主权项

1. A crystalline form of Vemurafenib hydrochloride salt, designated as Form II, characterized by one or more of the following:
a powder X-ray diffraction pattern having peaks at 5.0, 9.9, 15.7, 19.8 and 22.1 degrees two theta±0.2 degrees two theta; a powder X-ray diffraction pattern substantially as depicted in FIG. 1; a solid-state 13C NMR spectrum having characteristic peaks at 51.0, 114.5, 132.3, 138.0 and 139.5 ppm, ±0.2 ppm; a solid state 13C NMR spectrum having chemical shift differences between said characteristic peaks and a peak at 120.9 ppm±0.2 ppm of −69.9, −6.4, 11.4, 17.1 and 18.6±0.1 ppm, respectively; a solid state 13C NMR spectrum substantially as shown in FIG. 3; or any combination of these data.