主权项 |
1. A method of separating a secondary alcohol compound from a primary alcohol compound comprising: providing a mixture of a secondary alcohol compound and a primary alcohol compound; reacting the mixture with an amount of an acylating agent of formula 1 sufficient to acylate the primary alcohol compound in the presence of an acid catalyst to form a partially acylated mixture comprising the secondary alcohol compound and acylated primary alcohol compound, wherein R1 is a bulky group selected from the group consisting of branched C4-20 alkyl, C5-20 cycloalkyl, substituted C5-20 cycloalkyl, C6-20 aryl, and substituted C6-20 aryl; Y is selected from the group consisting of halogen, OH, and —O—C(O)—R1; and separating the secondary alcohol compound from the acylated primary alcohol compound, the separated secondary alcohol compound being substantially free of the primary alcohol compound; wherein the acylation step is free of metal catalysts and enzymatic catalysts; and wherein the secondary alcohol compound is separated from the acylated primary alcohol compound by one or more of distillation, column chromatography, or crystallization. |