T CELL GROWTH FACTOR

摘要

The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports interleukin 2- a nd interleukin 4-independent growth of helper T cells especially from murine and human sources and further which is capable of augmenting proliferation of IL3- or IL4-respon- sive cells. Even more particularly, the present invention relates to the helper T cell growth factor P40, pharmaceutical composi- tions thereof, antibodies thereto and recombinant DNA clones thereof. The present invention also contemplates a method for in- ducing the proliferation of helper T cells as well as IL3- and IL4-responsiv e cells. The helper T cells growth factor contemplated herein is useful in the stimulation of specific cells in the immune system, either alone or in combination with IL3 or IL4.