发明名称 |
Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease |
摘要 |
The invention provided for a method of directly and specifically transcriptionally modulating the expression of a gene encoding a protein of interest associated with treatment of one or more symptoms of a cardiovascular disease such as atherosclerosis, restenosis or hypertension. Further provided is a method of determining whether a molecule not previously known to be a modulator of protein biosynthesis is capable of directly and specifically transcriptionally modulating the expression of a gene encoding a protein of interest associated with treatment of one or more symptoms of a cardiovascular disease. Lastly, the invention provides a method of directly and specifically transcriptionally modulating in a human being the expression of a gene encoding a protein of interest associated with treatment of one or more symptoms of a cardiovascular disease, thus ameliorating the disease.
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申请公布号 |
US5580722(A) |
申请公布日期 |
1996.12.03 |
申请号 |
US19920832905 |
申请日期 |
1992.02.07 |
申请人 |
ONCOGENE SCIENCE, INC. |
发明人 |
FOULKES, J. GORDON;LIECHTFRIED, FRANZ E.;PIELER, CHRISTIAN;STEPHENSON, JOHN R.;CASE, CASEY C. |
分类号 |
A61K38/00;A61K48/00;C07K14/535;C07K14/61;C07K14/775;C12N9/02;C12N15/00;C12N15/65;C12N15/81;C12N15/85;C12Q1/68;(IPC1-7):C12P19/34 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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