Solid-phase process for making indole compounds

摘要

The subject invention involves a solid-phase process for the synthesis of indole compounds comprising the steps: (a) treating an amino resin with diketene to provide a resin-bound acetoacetamide; (b) treating the product from Step (a) with a primary amine in the presence of a dehydrating agent to provide a resin-bound enaminone; (c) treating the product from Step (b) with a 1,4-benzoquinone, and releasing the resulting indole product from the resin.