COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND AN ANTIOXIDANT AGENT FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS

摘要

The present invention provides compositions and methods for the treatment of central nervous system disorders. In some aspects, the invention provides a combination therapy for the treatment of a central nervous system ischemic mediated disorder comprising the administration to a subject of an antioxidant agent in combination with a cyclooxygenase-2 selective inhibitor. In other aspects, the invention provides a combination therapy for the treatment of a central nervous system disorder that is neurodegenerative comprising the administration to a subject of an antioxidant agent in combination with a cyclooxygenase-2 selective inhibitor.