发明名称 |
ARIPIPRAZOLE AND HALOPERIDOL PAMOATE SALTS |
摘要 |
The invention relates to the discovery that pamoate salts of haloperidol and aripiprazole result in a good to superior long acting and/or extended release profile. Thus, in one aspect of the invention, the invention includes pamoate salts of haloperidol or aripiprazole. Preferably, the pamoate salt is characterized by a ratio of haloperidol to pamoate of 1:1 or 2:1. The pamoate salt can be crystalline, such as a needle or a dense crystal, such as described in the Figures. The invention further relates to methods of treating an individual in need thereof comprising administering a pharmaceutical composition comprising a pamoate salt of haloperidol and aripiprazole. |
申请公布号 |
WO2005016261(A2) |
申请公布日期 |
2005.02.24 |
申请号 |
WO2004US24344 |
申请日期 |
2004.07.29 |
申请人 |
ALKERMES CONTROLLED THERAPEUTIC. II;GRECO, KRISTYN;WRIGHT, JAMES |
发明人 |
GRECO, KRISTYN;WRIGHT, JAMES |
分类号 |
A61K31/445;C07D211/52;(IPC1-7):A61K/ |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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