发明名称 |
PROTEINS |
摘要 |
A modified amyloid precursor protein can be expressed from a DNA construct comprising an APP DNA sequence, or a fragment or artificial substrate thereof, encoding the mutation I45W, I45Y, V46W or V46Y (numbering relative to A4CT); the use of the DNA construct in the generation of cell lines or transgenic animals and the use of these proteins or such transgenic animals in the diagnosis of Alzheimer's Disease and screening putative drugs against Alzheimer's Disease are also described. |
申请公布号 |
WO2006134342(A2) |
申请公布日期 |
2006.12.21 |
申请号 |
WO2006GB02157 |
申请日期 |
2006.06.13 |
申请人 |
MERCK SHARP & DOHME LIMITED;BEHER, DIRK;WRIGLEY, JONATHAN, DAVID |
发明人 |
BEHER, DIRK;WRIGLEY, JONATHAN, DAVID |
分类号 |
C07K14/47;C07K14/81;C12N15/85;G01N33/68 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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