PROCESS FOR PREPARING CRYSTALLINE FORM I OF OLANZAPINE

摘要

A process for preparing olanzapine Form I comprises: a) cooling a concentrated solution of olanzapine; b) isolating wet crystals of olanzapine Form I; and c) drying wet crystals and recovering olanzapine Form 1. Drying can be conducted by stepwise increases in the drying temperatures, with extended holding times at each temperature condition.