| 摘要 |
The present invention relates to a topical preparation for treating inflammatory skin diseases (dermatitis, including psoriasis and lichen ruber planus), in an ointment form containing sirolimus as active ingredient and a carrier formulated with all or some of the following components: ultra white petrolatum, mineral oil, glyceryl monostearate, anhydrous lanoline, white wax, N-methyl-2-pyrrolidone and antioxidant. The advantages of the present invention with respect to the state of the art compositions are based on the fact that the present composition contains an immunosupressing macrolide which acts specifically binding to a family of cytosolic immunophylins known as FKBP thus offering fewer adverse effects, compared to other agents used for treating inflammatory skin diseases which cause skin atrophy, nephrotoxicity, fibrosis and kidney function impairment. |
