发明名称 |
PAI-1 BINDING MODULATORS FOR THE TREATMENT OF OCULAR DISORDERS |
摘要 |
The invention concerns in one embodiment a method for treating glaucoma or elevated IOP in a patient comprising administering to the patient an effective amount of a composition comprising an agent that modulates PAI-1 binding to vitronectin. In another embodiment, the invention concerns a method of manufacturing a compound to be used as a treatment for glaucoma or elevated IOP comprising providing a candidate substance suspected of modulating PAI-1 binding, selecting the compound by assessing the ability of the candidate substance to decrease the amount of active PAI-1 in the trabecular meshwork of a subject suffering from glaucoma or elevated PAI-1, and manufacturing the selected compound. |
申请公布号 |
WO2008055205(A3) |
申请公布日期 |
2008.07.17 |
申请号 |
WO2007US83170 |
申请日期 |
2007.10.31 |
申请人 |
ALCON RESEARCH, LTD.;FLEENOR, DEBRA;PANG, IOK-HOU;CLARK, ABBOT |
发明人 |
FLEENOR, DEBRA;PANG, IOK-HOU;CLARK, ABBOT |
分类号 |
A61K31/122;A61K31/19;A61K31/41;A61P35/00 |
主分类号 |
A61K31/122 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|