| 发明名称 | Spalt-like transcription factor 4 (SALL4) and uses thereof | ||
| 摘要 | Described are methods of treating a solid tumor which expresses Spalt-Like Transcription Factor 4 (SALL4) and Phosphatase and Tensin Homolog (PTEN) in an individual in need thereof, comprising administering to the individual an effective amount of a composition that inhibits SALL4. In addition, the invention is directed to methods of detecting an aggressive cancer in an individual in need thereof as well as methods of detecting a poor prognosis of a patient with cancer in an individual in need thereof. | ||
| 申请公布号 | US9365851(B2) | 申请公布日期 | 2016.06.14 |
| 申请号 | US201214345603 | 申请日期 | 2012.09.20 |
| 申请人 | National University of Singapore;Brigham and Women's Hospital | 发明人 | Chai Li;Dimitrov Todor;Tenen Daniel Geoffrey;Yong Kol Jia;Liu Bee Hui |
| 分类号 | A61K38/10;C07K16/18;C07K7/08;C12N15/113;A61K38/17;G01N33/574 | 主分类号 | A61K38/10 |
| 代理机构 | Hamilton, Brook, Smith & Reynolds, P.C. | 代理人 | Hamilton, Brook, Smith & Reynolds, P.C. |
| 主权项 | 1. A method of treating a solid tumor which expresses Spalt-Like Transcription Factor 4 (SALL4) and Phosphatase and Tensin Homolog (PTEN) in an individual in need thereof, comprising administering to the individual an effective amount of a composition that inhibits SALL4 repression of PTEN expression, wherein the composition comprises a peptide having the amino acid sequence MSRRKQAKPQHI (SEQ ID NO: 1). | ||
| 地址 | Singapore SG | ||