Methods and compositions for promoting organ development

摘要

Compositions and methods are provided for promoting organ development in warm blooded animals, and in particular in certain aspects a premature infant or fetus. Compositions and methods are also provided for the administration of at least one colony stimulating factor-1 protein (CSF-1), precursor, variant, analog, derivative thereof, or combinations thereof, or otherwise, at least one nucleic acid molecule encoding colony stimulating factor-1 protein (CSF-1), precursor, variant, analog, derivative thereof, or combinations thereof.

主权项

1. A method of treating a warm blooded animal, comprising administering to the warm blooded animal a therapeutically effective amount of a composition comprising:
i) colony stimulating factor-1 protein (CSF-1) ii) a biologically active fragment of CSF-1; or iii) a biologically active CSF-1 analog comprising a region having at least 85% homology with a region of CSF-1 responsible for biological activity of CSF-1;wherein the treatment:
a) increases an organ weight in the warm blooded animal; and/or b) increases body weight of the warm blooded animal;wherein the warm blooded animal is a premature-birthed warm blooded animal or low birth weight warm blooded animal.