Bone cement mixing and delivery system and methods of use thereof

摘要

Bone cement mixing and delivery device and methods are disclosed. The device includes a first tube/barrel (e.g., a syringe barrel) containing a bone cement powder and a second tube/barrel that can be filled with or that contains a liquid; the first and second tubes/barrels can be fluidly connected end-to-end such that there is fluid communication between the tubes/barrels. Also disclosed are methods of preparing the device for use, methods for forming a bone cement using the device, and methods and device design to extend the shelf life of the device.

主权项

1. A bone cement mixing and delivery system comprising:
a first rigid tube comprising a first body having a constant inner diameter and a first tip having a smaller inner diameter than the inner diameter of the first body, and a first movable piston comprising a first rubber stopper at a terminal end thereof, the first rubber stopper having an outer diameter that is the same as the constant inner diameter of the first body, the first movable piston configured to be inserted rubber stopper-first into the first body of the first rigid tube opposite the first tip and prevent leakage of contents from the first rigid tube; a calcium phosphate bone cement powder, the first rigid tube is filled with a quantity of the calcium phosphate bone cement powder therein; a luer connector removably attached to the first tip; a porous cap configured to be removeably attached to the first tip of said first rigid tube via the luer connector, wherein said porous cap is configured to permit venting of gas, but not said calcium phosphate bone cement powder, from said first rigid tube; and a second rigid tube comprising a second body having a constant inner diameter and a second tip having a smaller inner diameter than the inner diameter of the second body, and a second movable piston comprising a second rubber stopper at a terminal end thereof, the second rubber stopper having an outer diameter that is the same as the constant inner diameter of the second body, the second movable piston configured to be inserted rubber stopper-first into the second body of the second rigid tube opposite the second tip and prevent leakage of contents from the second rigid tube; wherein said first rigid tube is configured to be joined tip-to-tip to said second rigid tube via the Luer connector such that, when joined, there is fluid communication between the tubes and an interior space is formed comprising an interior of the first rigid tube between the first rubber stopper of the first movable piston and the first tip of the first rigid tube and an interior of the second rigid tube between the second rubber stopper of the second movable piston and the second tip of the second rigid tube that is leak-tight against liquid at the time of the joining and throughout the joining, wherein the system is configured such that removable attachment of the porous cap to the tip of the first rigid tube via the luer connector and pressing of the movable piston of the first rigid tube and venting of gas but not the calcium phosphate bone cement powder from the first rigid tube forms a compressed calcium phosphate bone cement powder having a density of about 1.0 g/cc.