| 摘要 |
<p>RECOMBINANT HERPES SIMPLEX VIRUSES VACCINES AND METHODS A virus is disclosed which is rendered avirulent by prevention of expression of an active product of a gene which is designated as .gamma. 134-5, which maps in the inverted repeats flanking the long unique sequence of herpes simplex virus DNA, and which is not essential for viral growth in cell culture. Viruses from which the gene was deleted or which carried stop condons are totally avirulent on intracerebral inoculation of mice.</p> |
