发明名称 |
Substituted 3,4-dihydronaphthalenes, pharmaceutical compositions containing them, and preparation processes |
摘要 |
Substituted 3,4-dihydronaphthalenes of the formula I <IMAGE> wherein R1 is a methyl or an amino group, R2 represents a hydrogen atom or a methyl group, and R3 is a linear or branched chain alkyl residue having 1 to 4 carbon atoms, an allyl or a crotyl group or a cyclopentyl group are disclosed which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of disorders attributable to the action of leucotrienes. The dihydronaphthalenes may be prepared by reacting a compound of formula II <IMAGE> with hydroxylamine or a salt thereof to form the corresponding oxime, reducing the oxime to a hydroxylamine of formula III <IMAGE> and introducing a -CO-R1 group.
|
申请公布号 |
US5254731(A) |
申请公布日期 |
1993.10.19 |
申请号 |
US19920911625 |
申请日期 |
1992.07.10 |
申请人 |
GRUENENTHAL GMBH |
发明人 |
ZIMMER, OSWALD;VOLLENBERG, WERNER;SCHNEIDER, JOHANNES |
分类号 |
A61K31/16;A61K31/17;A61P11/00;A61P11/06;A61P11/08;A61P31/04;A61P37/08;A61P43/00;C07C259/06;C07C275/64;(IPC1-7):C07C53/06 |
主分类号 |
A61K31/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|