发明名称 |
USE OF 17.ALPHA.-DIHYDROEQUILENIN FOR LOWERING CHOLESTEROL |
摘要 |
2148357 9409789 PCTABS00032 This invention provides a method of lowering cholesterol and blood lipid levels, preventing hypercholesterolemia, hyperlipidemia, cardiovascular disease, atherosclerosis, and peripheral vascular disease comprising administering an effective amount of 17.alpha.-dihydroequilenin or a mammalian metabolic conjugate thereof, including a pharmaceutically acceptable salt thereof, to a mammal in need thereof. The invention also provides a compound for use as a pharmaceutical, the compound being selected from 17.alpha.-dihydroequilenin, a mammalian metabolic conjugate thereof and their pharmaceutically acceptable salts. The invention also provides a pharmaceutical composition comprising the said compound in association or combination with a pharmaceutical carrier.
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申请公布号 |
CA2148357(A1) |
申请公布日期 |
1994.05.11 |
申请号 |
CA19932148357 |
申请日期 |
1993.11.01 |
申请人 |
AMERICAN HOME PRODUCTS CORPORATION;WAKE FOREST UNIVERSITY |
发明人 |
WASCHBURN, SCOTT ALAN;CLARKSON, THOMAS BOSTON;ADELMAN, STEVEN JAY;DEY, MICHAEL STEVEN |
分类号 |
A61K31/565;A61K31/585;A61P3/06;A61P9/08;A61P9/10;(IPC1-7):A61K31/565 |
主分类号 |
A61K31/565 |
代理机构 |
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地址 |
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