发明名称 |
Hydroxamic acid derivative |
摘要 |
<IMAGE> A compound represented by general formula (I), a pharmaceutical composition containing same, a process for the production thereof, and an intermediate therefor. In formula (I) R1 represents lower alkyl which may be substituted by a substituent selected from the group consisting of mercapto, lower alkylthio, arylthio and lower acylthio; R2, R3 and R4 may be the same or different from one another and each represents lower alkyl; X represents oxygen or sulfur; and Y represents a single bond or lower alkylene. The compound (I) has a matrix metalloprotease inhibitory activity and is useful for preventing and treating diseases caused by the progress of connective tissue breakage.
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申请公布号 |
US5473100(A) |
申请公布日期 |
1995.12.05 |
申请号 |
US19950409709 |
申请日期 |
1995.03.24 |
申请人 |
YAMANOUCHI PHARMACEUTICAL CO., LTD. |
发明人 |
ISOMURA, YASUO;AKAMATSU, SEIJIRO;YODEN, TORU;KUDOU, MASAFUMI;SUGA, AKIRA |
分类号 |
A61K31/165;A61K31/19;A61K31/215;A61K31/265;A61P1/02;A61P27/02;A61P29/00;A61P43/00;C07C237/22;C07C259/06;C07C323/57;C07C323/60;C07C327/30;C07C327/32;C07C327/34;(IPC1-7):C07C259/04 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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