CELLULAR REGULATORS OF INFECTIOUS AGENTS AND METHODS OF USE

摘要

The invention provides ribozymes with target recognition sequences that allow the ribozyme to target and cleave cellular regulators that are involved in HCV and other viral replication. Also provided are nucleic acids encoding various cellular regulators and sequences in such nucleic acid for which ribozymes can be directed. Fragments of these nucleic acid and protein sequences also are provided. Further provided is a method for identifying a ribozyme reactive with a cellular regulator of viral replication or expression, and a method for identifying the cellular regulator targeted by such ribozymes. Also provided is a method of identifying a compound that modulates the activity of a cellular regulator. Further provided is a method of treating an HCV infection.