Novel sequence information and methods for its use in diagnosis and therapy XIII

摘要

The present invention relates antisense oligonucleotide compounds for use in modulating the function of nucleic acid molecules encoding mammalian MMP-12. More specifically, the invention provides compounds of 8 to 50 nucleobases in length capable of specifically hybridising with nucleic acid molecules encoding MMP-12 and thereby inhibiting the expression of the MMP-12 protein product, as well as pharmaceutical compositions thereof and methods of its use.