Polyoxyalkylene compound and method for making

摘要

A process for forming a conjugate of a polyoxyalkylene polymer (such as polyethylene glycol) with a compound containing an amine group(s) and/or a sulfide group(s) by reacting the compound with an acrylate terminated polyoxyalkylene (such as polyethylene glycol terminate at one end with acrlyate or methacrylate and terminated at the other end with a methoxy group). The reaction is believed to be a Michael addition. When the compound contains primary amine groups (such as the surface primary amine groups of a PAMAM dendrimer), it is usually desirable to convert the primary amine groups to secondary amine groups before the reaction with the acrylate terminated polyoxyalkylene.