METHOD FOR INTRODUCING NUCLEIC-ACID-PROTECTING GROUP

摘要

The object is to provide a method for introducing a substituent (I) into a 2'-hydroxyl group of a ribose moiety in a ribonucleic acid derivative having a 3'-hydroxyl group and a 5'-hydroxyl group each protected by a silicon protecting group, in a simple manner and at a low cost. (I) wherein WG¹ represents an electron-attracting group. Disclosed is a method for producing a ribonucleic acid derivative represented by the general formula (3) by reacting a ribonuleic acid derivative represented by the general formula (1) with a monothioacetal compound represented by the general formula (2), wherein iodine is used as a reagent for the halogenation of a sulfur atom in the monothioacetal compound (2) in the presence of an acid. (2) (1) (3) wherein Bz represents a nucleotide which may have a protecting group; WG¹ represents an electron-attracting group; R³ represents an alkyl or aryl group; and A represents a silicon substituent.