摘要 |
The invention provides non-steroidal estrogenic compounds with estrogenic and anti-estrogenic compounds effects for treatment of estrogen-deficiency related disorders, which compounds are having formula (I) wherein, one of R<a >or R<b >is 'R<e>; R<e >and 'R<e >are OH, optionally independently etherified or esterified; X is N or -C(R<1>)-, wherein R<1 >is H1 halogen, CN, optionally substituted aryl, (1C-4C)alkyl, (2C-4C)alkenyl, (2C-4C)alkynyl or (3C-6C)cycloalkyl, which alkyl, alkenyl, alkynyl and cycloalkyl groups can optionally be substituted with one or more halogens; Y is N or -C(R<2>)-, with the proviso that X and Y are not both N, wherein R<2 >has the same meaning as defined for R<1>; Z is C(R<3>,'R<3>)- or -C(R<4>,∝R<4>)-C(R<5>,'R<5>)-, wherein R<3>, 'R<3>, R<4>, 'R<4>, R<5>, and 'R<5>, independently arc H, (1C-4C)alkyl, (2C-4C)alkenyl or (3C-6C) cycloalkyl, which alkyl, alkenyl and cycloalkyl groups can optionally be substituted with one or more halogens. These compounds are useful for estrogen-receptor related treatments in view of a desirable profile of activity for estrogen alpha and estrogen beta receptors. |