Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity

摘要

Compounds of formula (I) described herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

主权项

1. A compound represented by formula (I) wherein
Q is a group of formula Q1 or Q2 Z is H or OH;Y is Y′ or Y1 which are divalent groups of formula: wherein
A1 is butylene;A2 is absent or (C1-C6)alkylene;B is selected from the group consisting of pyrazolediyl and thiophenediyl, each of which is optionally substituted by one or more methyl groups;C is —OC(O)— or is a group C1 wherein R4 is H;D is absent;n′ is 1;E is absent or is —O—;G is phenylene;R1 is H;R2 is H or aryl;R3 is a group of formula J1 or J2 wherein R5 is a group of formula K wherein p′ is 0 or 1, P is absent or is CO, q is absent or is 1 and W is heteroaryl, or a pharmaceutically acceptable salt thereof.