Pharmaceutical composition with enhanced efficacy for inhibiting angiogenesis

摘要

The present invention relates to a pharmaceutical composition for inhibiting angiogenesis and a novel sulfonyl amide derivative compound which can be useful for the prevention or treatment of angiogenesis-related diseases or disorders. Since the compound used as an active ingredient in the pharmaceutical composition of the invention is specifically bound to UQCRB and inhibits biological functions thereof, apoptosis is not induced and angiogenic responses are inhibited. Therefore, the compound used as an active ingredient in the pharmaceutical composition of the invention can be useful as an effective and safe angiogenesis inhibitory agent.

主权项

1. A pharmaceutical composition comprising a compound represented by Chemical Formula 1: wherein R1 is selected from the group consisting ofnaphthalyl, and naphthalyl substituted with C1-C6 alkyl;
R2 is selected from the group consisting ofhydroxynaphthalyl, and 4-(2-hydroxyethyl)cyclohexyl;
A1 is C1-C6 alkyl or phenyl; and B1, B2, B4, and B5 are each independently selected from the group consisting of H—, halo, hydroxyl, nitro, and C1-C6 alkyl, and B3 is selected from the group consisting of H—, halo hydroxyl, and C1-C6 alkyl.