| 摘要 |
PROBLEM TO BE SOLVED: To provide an ACTRIIA binding agents and uses thereof.SOLUTION: The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIA and uses thereof. The disclosure provides, among other aspects, antibodies and fragments thereof that bind to ActRIIA and inhibit ActRIIA- or activin-mediated signaling. A variety of uses for such proteins are described herein. For example, the antibodies may be used to increase muscle mass or lean body mass in patients having diseases or conditions that are characterized by muscle loss or damage, to decrease FSH in patients in need thereof, to treat cachexia, particularly cancer cachexia, to decrease adiposity and thereby treat disorders such as obesity, and as part of assays to identify known and novel ActRIIA-binding agents.SELECTED DRAWING: None |
