| 发明名称 |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| 摘要 |
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR. |
| 申请公布号 |
US2016201058(A1) |
申请公布日期 |
2016.07.14 |
| 申请号 |
US201514965816 |
申请日期 |
2015.12.10 |
| 申请人 |
Thermo Fisher Scientific Inc. |
发明人 |
Khvorova Anastasia;Reynolds Angela;Leake Devin;Marshall William;Read Steven;Scaringe Stephen |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An siRNA molecule, wherein said siRNA molecule consists of: (a) a duplex region; and (b) either no overhang regions or at least one overhang region, wherein each overhang region contains six or fewer nucleotides, wherein the duplex region consists of a sense region and an antisense region, wherein said sense region and said antisense region together form said duplex region and said sense region and said antisense region are each 19-30 nucleotides in length and said antisense region comprises a sequence that is the complement of a sequence selected from the group consisting of SEQ ID NOs: 438-481. |
| 地址 |
Lafayette CO US |
