发明名称 |
Methods of treating Parkinson's disease |
摘要 |
Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof. |
申请公布号 |
US9415025(B2) |
申请公布日期 |
2016.08.16 |
申请号 |
US201514977251 |
申请日期 |
2015.12.21 |
申请人 |
The Hospital for Sick Children;McMaster University |
发明人 |
Mahuran Don J.;Tropak Michael B.;Buttner Justin D.;Blanchard Jan E.;Brown Eric D. |
分类号 |
A61K31/58;A61K31/56;A61K31/553;A61K31/54;A61K31/137 |
主分类号 |
A61K31/58 |
代理机构 |
InHouse Patent Counsel, LLC |
代理人 |
Wales Michele M.;InHouse Patent Counsel, LLC |
主权项 |
1. A method of reducing the symptoms of Parkinson's Disease in a patient comprising administering to the patient ambroxol, ambroxol hydrochloride, or bromhexine, or a pharmaceutically acceptable salt thereof at a dose of 250-500 mg administered once, twice, three or four times a day. |
地址 |
Toronto CA |