Compositions and methods for sensitizing a neoplastic cell to radiation

摘要

The invention provides for the use of radiation sensitizing agents in combination with radiation for the treatment of neoplasia, methods for the identification of genotype-specific radiation sensitizing agents, and methods of identifying patients who could benefit from therapy with a genotype-specific radiation sensitizing agent.

主权项

1. A method of sensitizing a non small cell lung cancer cell to radiation, the method comprising contacting the cell with a PI3 kinase inhibitor and exposing the cell to radiation, thereby sensitizing the cell to radiation, wherein the cell comprises a NFE2L2 mutation.